For any styles in WPF, you should have a separate resource dictionary that contains the styles for your app.
If you want to have a single Font Size that's reused throughout the app then just create a style for that font size. You can either give it a unique name/key to use explicitly or you can set a targetType that will transcend throughout the app.
That way, if I want to change ALL the controls, I'd just have to change the "baseStyle" style, the rest would just inherit from it. (That's what BasedOn property those, you can also extend the base style if you create other setters inside of the inherited style)
If you need to programmatically change global FontSize, not statically (XAML), to be applied once for all your windows, you can do:
TextElement.FontSizeProperty.OverrideMetadata(
typeof(TextElement),
new FrameworkPropertyMetadata(16.0));
TextBlock.FontSizeProperty.OverrideMetadata(
typeof(TextBlock),
new FrameworkPropertyMetadata(16.0));
This values are applied to any TextBlock, Labels and almost any text in any windows, whereas it has not a explicit FontSize defined. But this does not affect for TextBox, you have to write a similar code for it or any other special controls.
TextElement.FontSize is an inherit property, which means you can simply set the font size at root element, and all the children elements will use that size (as long as you don't change them manually)
Using Resources in XAML is the way to go. Although there are many great answers to this question, I would like to add my two cents to the SCOPE of the Resource.
For Global accessibility in all of the Windows and User Controls of the Project, you can have your resource in the App.xaml file