Thread Safety means that binary can work in a multithreaded webserver context, such as Apache 2 on Windows. Thread Safety works by creating a local storage copy in each thread, so that the data won't collide with another thread.
So what do I choose? If you choose to run PHP as a CGI binary, then you won't need thread safety, because the binary is invoked at each request. For multithreaded webservers, such as IIS5 and IIS6, you should use the threaded version of PHP.
So it really depends on the way that you want to use PHP:
In addition to Crack, since 5.4 you can use built-in web server (it works nice!).
Warning This web server was designed to aid application development.
It may also be useful for testing purposes or for application
demonstrations that are run in controlled environments. It is not
intended to be a full-featured web server. It should not be used on a
public network.
Quick and simple: If you are using Apache edit your Apache24\conf\httpd.conf file and search for "loadmodule". If you see your loadmodule is referencing a .dll something like: