The first part of your question is easy. As already pointed out, cut accepts omission of either the starting or the ending index of a column range, interpreting this as meaning either “from the start to column n (inclusive)” or “from column n (inclusive) to the end,” respectively:
However, the second part of your question can be a bit trickier depending on what kind of input you’re expecting. If by “last n columns” you mean “last n columns (regardless of their indices in the overall row)” (i.e. because you don’t necessarily know how many columns you’re going to find in advance) then sadly this is not possible to accomplish using cut alone. In order to effectively use cut to pull out “the last n columns” in each line, the total number of columns present in each line must be known beforehand, and each line must be consistent in the number of columns it contains.
If you do not know how many “columns” may be present in each line (e.g. because you’re working with input that is not strictly tabular), then you’ll have to use something like awk instead. E.g., to use awk to pull out the last 2 “columns” (awk calls them fields, the number of which can vary per line) from each line of input: