I would do an interactive rebase on HEAD~2 and squash the last two commits together. Assuming that you want to keep the history as is in Branch1 and simplify it in Branch2, do the following (current branch Branch1):
A new editor will open up where you can specify the new commit message. It would probably now just read
Changed File2
Close it and you're done, both commits are squashed together on Branch2 and Branch1 retains your original history. Note that if you don't need to retain the original history, you can just skip checking out Branch2 and work directly on Branch1. Only do that if you haven't published your last two commits on Branch1 already.