Binary, decimal, hexadecimal... the base only matters when reading or outputting numbers, adding binary numbers is just the same as adding decimal number : it is just a matter of representation.
I think you're confused about what binary is. Binary and decimal are just different representations of a number - e.g. 101 base 2 and 5 base 10 are the same number. The operations add, subtract, and compare operate on numbers - 101 base 2 == 5 base 10 and addition is the same logical operation no matter what base you're working in. The fact that your python interpreter may store things as binary internally doesn't affect how you work with it - if you have an integer type, just use +, -, etc.
If you have strings of binary digits, you'll have to either write your own implementation or convert them using the int(binaryString, 2) function.
If you're talking about bitwise operators, then you're after:
~ Not
^ XOR
| Or
& And
Otherwise, binary numbers work exactly the same as decimal numbers, because numbers are numbers, no matter how you look at them. The only difference between decimal and binary is how we represent that data when we are looking at it.
I think you're confused about what binary is. Binary and decimal are just different representations of a number - e.g. 101 base 2 and 5 base 10 are the same number. The operations add, subtract, and compare operate on numbers - 101 base 2 == 5 base 10 and addition is the same logical operation no matter what base you're working in.
You can remove the zeroes and then add them again after you do your calculation! This works very easy.
If your binary is stored as a string then you can convert to int which will automatically strip the zeroes from the start. After you have your answer you can turn it back into a string and add the zeroes to the start.